Some much-needed relief from the oppressive heat is on the way for the Plains and Midwest, but the focus now is on the southeastern U.S., where temperatures will continue to soar into the upper 90s and lower 100s on Wednesday.
NOAA's Weather Prediction Center says a cold front sweeping eastward through the Ohio Valley will result in a cooling trend, with temperatures in the lower 90s on Wednesday dropping to the 80s on Thursday.
But the hot weather will continue across the Southern Plains and the Southeast, where several record-high temperatures are in jeopardy of falling Wednesday afternoon.
As a result, heat alerts are in effect for millions of Americans, warning them to take precautions to prevent heat-related illnesses such as heatstroke.
Some major cities across the region are included in Heat Advisories, which will remain in effect until at least Thursday.
Those cities include Tulsa, Oklahoma, where the National Weather Service says it could feel like 106 degrees by the afternoon.
Most of Mississippi is included in those advisories, as well as the Birmingham, Alabama, area. The NWS is also saying the heat and humidity could make it feel like 105 degrees by Thursday afternoon.
Portions of Middle Georgia, including the Macon area, are under Excessive Heat Watches. The NWS says temperatures will soar above 100 degrees during the day, and the humidity will make it feel around 105 degrees as well.
Temperatures are generally forecast to be in the upper 90s across the Southeast, but several locations will be hotter than that.
Dallas/Fort Worth, Jackson, Mississippi, and New Orleans are expected to be about 98 degrees on Wednesday, with areas to the north, like Little Rock, Arkansas, getting very close to 100 degrees.
Tallahassee, Florida, and Columbia, South Carolina, will be above the century mark, with a high temperature in both cities around 102 degrees.
Those temperatures are excessively hot, but the humidity will make it feel even hotter.
It will feel well above 100 degrees in major cities across the region.
Dallas and Houston will feel like 101 and 102 degrees, respectfully.
Jackson, Mississippi, and New Orleans will feel like it's 105 degrees, with Tallahassee to the east feeling like 102.
Most people living in the region know that it can get downright oppressive as the summer rolls on, but the temperatures on Wednesday will be hot enough to break several records.
Macon and Augusta, Georgia, could see their old records fall Wednesday as temperatures get above 100 degrees.
Interior South Carolina will also be baking, and Columbia, the capital city, could see its old record fall if the city reaches 102 degrees.
For the millions of Americans expected to really feel the heat again on Wednesday, precautions need to be made to prevent heat-related illnesses.
Extreme heat and humidity significantly increase the potential for heat-related illnesses, particularly for those working or participating in outdoor activities. The best time to be outdoors would be early in the morning or later in the evening.
If you need to go outdoors during the day, wear loose, lightweight and light-colored clothing and drink plenty of fluids.
Always "look before you lock" to ensure you have not left any children or pets inside a car. Temperatures inside a locked vehicle with the windows rolled up can be deadly.
Track the temperatures in your area with the FOX Weather app. The free FOX Weather livestream is also available 24/7 on the website and app and on your favorite streaming platform. The FOX Weather Update podcast also provides weather information for the entire country.