The town is less than an hour's drive outside Tallahassee and video taken by storm tracker Michael Gordon showed damaged homes and debris blocking roadways.
The local sheriff's department reported widespread damage in the rural county, and damage assessments were underway.
PowerOutage.us reported nearly 80 percent of Liberty County was without electricity and the local utility provider did not say when all power will be restored.
"It has been confirmed that a tornado has hit the Hosford area. All students at Hosford school are accounted for and safe. There is a large amount of debris and power lines down in the area. Please stay off the roads as emergency teams work to manage this situation," the Liberty County Sheriff's Department stated.
According to NWS meteorologists, the twister was on the ground for more than 2.5 miles in Liberty County before lifting and moving over communities closer to the state's capital.
The tornado was one of about half a dozen suspected touchdowns in the Florida Panhandle, with many other witness accounts of hail and damaging winds.
There were no initial reports of significant injures from any of the storms.
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